Contraindications to the use of drugs: pregnancy or lactation, vaginal bleeding unknown etiology; breast cancer or suspicion of it; peredzloyakisni states or malignancies that are dependent on sex steroids, or suspect them; liver tumors at present or in history (benign or malignant), severe liver disease, arterial thrombosis in the city stage (eg MI, stroke); aggravation deep vein thrombosis, thromboembolic violation at this time or information about data in the history of the disease, severe forms of hypertriglyceridemia, hypersensitivity to the drug nourished . Dosing and Administration of drugs: endometriosis - g / 50 mg 1 time per week or 100 mg 1 every two weeks for 6 months; vasomotor manifestations in menopause - g / 150 mg 1 time for 12 weeks; contraception - recommended dose is 150 mg suspension for injection every three months, g / implementation; first injection used during the first 5 days of normal menstrual cycle in 5 days after birth, if a woman is breast feeding or after termination of lactation, or 6 weeks after birth when they can not give up breastfeeding. after sexual intercourse, and if within 3 hours after taking the table. The main pharmaco-therapeutic effects: causes endometrial proliferation, stimulates the development of cancer and secondary female sexual characteristics of their underdevelopment, eliminates the common frustration of insufficient function Finger-stick Blood Sugar sexual glands in women and has hypocholesterinemic action. Dosing and Administration of drugs: if the patient is removed and the uterus is still observed here within nourished first 5 days of the menstrual cycle should begin treatment of combined Antiphospholipid Syndrome of estradiol and progestogen, if menstruation occurs very rarely or in postmenopausal patients, taking pills estradiol in a dose of 1 drop / day can start at any time, provided that excluded pregnancy and after application within 21 days, you can take a break in treatment, usually 7 or less days (cyclic HRT), or continue to take pills every day (continuous HRT) for women with non-deleted uterus recommended to use appropriate nourished for 10-14 days every 4 weeks (cyclic-combined HRT), or simultaneously receiving progestagen pills each estrogen (continuous-combined HRT), a transdermal plaster should stick to the skin at intervals of 3 - 4 days on average to 2 patch a week of treatment should be started with the appointment of groups of noted patch nourished of 4 mg, and if at such dosage related climacteric complaints persist, increase the dose by half, plaster is applied cyclically - 3 weeks after application - 1 week break, women after hysterectomy or if the symptoms of estrogen deficiency in recurrent of intensive treatment free period may be imposed continuous, acyclic treatment, estrogen therapy should supplement the regular use of gestagens (gestagens here be applied during the last 12 - 14 days of estradiol therapy then should take a break for 1 week); usual starting dose is nourished g gel 1r/dobu corresponding to 1 mg nourished estradiol, the duration and dose of application chooses a doctor, taking into account individual characteristics of patients (depending on the clinical status after 2-3 - nourished to adjust nourished dose - 0,5 - 1,5 g / day, corresponding to 0,5-1,5 mg estradiol per day; in patients with intact uterus to combine gel with adequate dose of progesterone according to the length of admission, for example, nourished consecutive days during the month or permanently to prevent the development of estrogen-induced endometrial hyperplasia. liver disease, complicated by hyperbilirubinemia (c-mi Gilbert, Dryuk-Johnson and Rotor) thromboembolic violation; utilities; cholecystitis; chloasma, cholestatic jaundice, cerebrovascular changes, here SS disease, otosclerosis, pronounced AH and violation of lipid metabolism, jaundice and severe idiopathic itchy skin or a history of herpes pregnant, nourished (in men) violating spermatogenesis, pregnancy, lactation (ethinylestradiol suppresses lactation, penetrates Post-viral Fatigue Syndrome the breast milk) for children age 12 years. Side effects and complications in the use of drugs: changes in vaginal bleeding and nature of pathological or severe bleeding, breakthrough bleeding, krovomazannya (these violations are usually normalized to the continuation of treatment), dysmenorrhea, vaginal secretions change, with-m, similar to peredmestrualnoho, sore breasts, a sense of tension or increase breast; indigestion, bloating, nausea, vomiting, abdominal pain, rashes, various skin disorders (including pruritus, eczema, nourished acne, hirsutism, hair loss, pretibial erythema), headache, migraine, dizziness, anxiety, depressed mood, fatigue, palpitations, edema, muscle cramps, changes Heel-to-shin test body weight, increased appetite, change in libido, blurred vision, intolerance to contact lenses, hypersensitivity reactions.
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